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Applying whole genome sequencing

  • Serological tests were not able to discriminate the disease isolates, obtaining the whole genome sequence for each isolate will provide information to allow differences in the DNA sequence of isolates to be detected if it exists.

  • Whole genome sequencing and genomics can discriminate to a high degree, sufficient to identify if meningococcal strains are part of the same close transmission network.

  • The incident team decides to sequence and analyse eight genomes from the University outbreak (4 cases and 4 contacts) along with two genomes from the remote cases and two reference genomes from well characterised meningococcal strains.

  • The output from this analysis is made available to you to use in the outbreak investigation

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